Avana 100 mg (avanafil 100 mg), there isn't a particular brand of Avana 100 mg that is proven to have fewer drug interactions. The active ingredient—avanafil—is what determines the interactions, assuming the product is genuine and contains the stated dose. Avanafil has important interactions with: Nitrates (e.g., nitroglycerin): do not use together because of potentially dangerous low blood pressure. Strong CYP3A4 inhibitors such as ritonavir, ketoconazole, and clarithromycin: avanafil should generally not be used with these. Moderate CYP3A4 inhibitors such as erythromycin, diltiazem, fluconazole, and verapamil: the maximum recommended avanafil dose is 50 mg, not 100 mg. Alpha-blockers and blood-pressure medicines: can increase the risk of low blood pressure and dizziness. Large amounts of alcohol: can increase blood-pressure lowering and dizziness. D dailymed.nlm.nih.gov +1 So Avana 100 mg isn't necessarily a better choice simply because it may have fewer interactions than another ED medicine. If you tell me the medicines/supplements you currently take, I can check the specific interactions with avanafil.