The shortage began in early 2020 and has been ongoing since then. While the exact cause of the shortage is unclear, it appears to be related to a manufacturing issue. The manufacturer of the drug, Mallinckrodt Pharmaceuticals, has experienced supply chain issues due to the pandemic that have caused the shortage. This has led to Fioricet becoming increasingly difficult to find, and prices for the drug have skyrocketed.

The shortage has created a great deal of frustration and anxiety for those who rely on the drug. Many have had to switch to alternative medications, which may not be as effective as Fioricet. Others have had to go without the drug altogether. This can be especially challenging for those with chronic headaches, as they may find it difficult to manage their pain without the drug.