Vidalista 40 mg contains tadalafil, and tadalafil can affect blood pressure and cardiovascular function. It does not generally cause heart problems in healthy people, but it can be risky for people with certain cardiovascular conditions. Important precautions: Do not take tadalafil with nitrate medicines such as nitroglycerin, because blood pressure can fall dangerously. Extra caution is needed with unstable angina, recent heart attack or stroke, uncontrolled blood pressure, or certain serious heart conditions. Tadalafil can cause a temporary decrease in blood pressure, particularly when combined with certain blood-pressure medicines, alpha-blockers, or substantial alcohol. Chest pain during or after ***** activity requires immediate medical attention. Also, 40 mg is higher than the usual tadalafil dose used for erectile dysfunction; standard ED tablets are generally 2.5–20 mg. If someone has known heart disease or takes heart medication, they should discuss Vidalista 40 mg with a doctor before using it.