Super P-Force Oral Jelly contains sildenafil + dapoxetine, it is best to avoid grapefruit and grapefruit juice while using it. You should not use Super P-Force Oral Jelly with grapefruit in these situations: On the same day as your dose: Grapefruit can inhibit the CYP3A4 enzyme that helps break down sildenafil, increasing the amount of the drug in your bloodstream. If you are prone to side effects: Higher sildenafil levels may increase the risk of headache, flushing, dizziness, low blood pressure, fainting, or vision changes. If you have heart disease or low blood pressure: The combination of grapefruit and sildenafil may further increase the risk of a significant drop in blood pressure. If you take medicines that also affect CYP3A4 (such as ketoconazole, itraconazole, ritonavir, or clarithromycin): Grapefruit can add to these effects and further increase drug levels. For safety, many experts recommend avoiding grapefruit and grapefruit juice entirely while taking sildenafil-containing medicines. If you have already consumed grapefruit, waiting at least 24 hours before taking sildenafil is a prudent approach because the interaction can persist beyond the meal itself.