Vilitra 60 contains vardenafil, a medication used for erectile dysfunction. Its interaction with other medications can be significant, and it’s important to be aware of the main categories of drugs that may interact with it. Here’s a detailed breakdown: 1. Nitrates Medications like nitroglycerin, isosorbide dinitrate, or isosorbide mononitrate (used for angina) can cause dangerous drops in blood pressure when taken with Vilitra 60. Interaction level: Severe – should never be combined. 2. Alpha-blockers Drugs for prostate enlargement or high blood pressure (e.g., tamsulosin, doxazosin) may cause low blood pressure, dizziness, or fainting if taken with Vilitra. Management: Start with a low dose and monitor blood pressure closely. 3. CYP3A4 inhibitors Medications like ketoconazole, itraconazole, ritonavir, or clarithromycin can increase vardenafil levels, raising the risk of headache, dizziness, or priapism. Management: Dose adjustment may be necessary. 4. Other erectile dysfunction drugs Combining Vilitra 60 with other PDE5 inhibitors (e.g., sildenafil, tadalafil) is not recommended due to additive effects on blood pressure and potential heart risks. 5. Other medications Antihypertensives: Can add to blood pressure-lowering effects. Grapefruit juice: May increase vardenafil levels by inhibiting CYP3A4.