Malegra FXT Plus, a combination of Sildenafil Citrate (100 mg) and Fluoxetine (60 mg), typically begins to take effect within 30 to 60 minutes after ingestion. The duration of its effects generally lasts between 4 to 6 hours, depending on individual factors such as metabolism, overall health, and adherence to usage guidelines . Sildenafil, the active ingredient for erectile dysfunction, has a half-life of about 4 hours, meaning its concentration in the bloodstream decreases by half in that time. Fluoxetine, the component addressing premature *****, has a significantly longer half-life—approximately 1 to 3 days for the parent drug and 4 to 6 days for its active metabolite, norfluoxetine . This extended half-life means Fluoxetine remains in your system much However, the noticeable effects of Malegra FXT Plus, such as improved erectile function and delayed *****, typically diminish within the 4 to 6-hour window. Beyond this period, while Fluoxetine may still be present in your system, its impact on ***** performance is minimal. It's important to note that the medication should not be taken more than once every 24 hours. Consulting a healthcare provider before use is essential, especially if you have underlying health conditions or are taking other medications.