Duratia 90 mg (dapoxetine) is a selective serotonin reuptake inhibitor (SSRI) used to treat premature ***** (PE) in men. One of the common side effects of dapoxetine (and other SSRIs) is fatigue or drowsiness, which can occur in some individuals. When Can Duratia 90 mg Cause Fatigue? 1. Timing After Taking the Medication: Fatigue from Duratia 90 mg typically develops after ingestion, especially as the medication starts to affect serotonin levels in the brain. The onset of fatigue is often experienced within 1 to 3 hours after taking the medication, as this is the period when the drug begins to work. For some men, drowsiness can persist for several hours after taking the medication. 2. Higher Doses (90 mg): Fatigue may be more pronounced when using a higher dose, like 90 mg, as the body may have a stronger reaction to the higher serotonin modulation. If a lower dose (such as 30 mg) works well for you, the 90 mg dose might be more likely to cause side effects like fatigue or drowsiness. It's important to note that side effects like fatigue may also be dose-dependent, meaning that higher doses may increase the likelihood or severity of tiredness. 3. Alcohol Consumption: Combining Duratia 90 mg with alcohol can increase the risk of fatigue. Alcohol can amplify the sedative effects of the medication, leading to heightened drowsiness, dizziness, and fatigue. It’s generally advised to limit alcohol while using Duratia to avoid such interactions. 4. Individual Sensitivity: Some individuals are more sensitive to SSRI medications, and their bodies may react more strongly to the serotonin increase caused by Duratia. This can result in increased tiredness or drowsiness, even with a standard dose. If you are particularly sensitive to medications like SSRIs, you might experience fatigue even at lower doses (like 30 mg), but higher doses like 90 mg could be more pronounced. 5. Other Factors Contributing to Fatigue: Underlying health conditions: Men with liver or kidney problems, or those with a history of depression, may experience more pronounced fatigue when using Duratia. Medication interactions: Taking Duratia with certain other medications (especially other SSRIs, antidepressants, or medications affecting serotonin) may increase the likelihood of side effects like fatigue. 6. Fatigue as a Side Effect: Drowsiness or fatigue is one of the more common side effects reported with Duratia (especially in the first few uses), and it typically subsides after a few hours. However, if fatigue persists or worsens, it may indicate that the medication is not suitable for you at this dose, and you should consult your healthcare provider.