Tadact 20 mg (tadalafil) is not significantly affected by meals. It can be taken with or without food, including after a normal or relatively heavy meal. Food does not meaningfully change tadalafil's absorption or overall exposure. D DailyMed +1 A few practical points: You don't need to take Tadact 20 mg on an empty stomach. Tadalafil generally reaches its maximum blood concentration around 2 hours after a dose, although the timing varies between people. D DailyMed Unlike sildenafil, tadalafil's effectiveness is not substantially reduced by a high-fat meal. Avoid excessive alcohol, as combining it with tadalafil can increase dizziness and blood-pressure lowering. Do not combine Tadact with other ED medicines such as sildenafil, vardenafil, or udenafil. If you're deciding between Tadact 20 mg and Vigora 100 mg, I can also explain how food, onset, duration, and side effects differ between them.